Researcher Okada from Toxicology & Pathology to Present a Poster at the 54th Annual Meeting of the Japanese Environmental Mutagen and Genome Society (JEMS)

Our researcher, Kumiko Okada from the Toxicology & Pathology group, will deliver a poster presentation at the 54th Annual Meeting of the Japanese Environmental Mutagen and Genome Society (JEMS), to be held from November 22 to 23, 2025, in Japan.
If you plan to attend the conference, we encourage you to join the session and hear the presentation.

Conference Name: the 54th Annual Meeting of the Japanese Environmental Mutagen and Genome Society (JEMS)

Date & Time: November 23, 13:35-14:35 (JST)

Location: University of Shizuoka, Kusanagi Campus, Shizuoka prefecture, Japan

Title: Study on the Detection of Weak Mutagens Using the Miniaturized Ames Test with Pre-Incubation Method

Poster Number: P-46

Presentation Summary
The Ames test is a common method for evaluating the mutagenicity of pharmaceuticals and chemicals. Axcelead has previously provided “Miniaturized Ames tests” using TA98 and TA100, suitable for screening applications. In this study, we conducted a miniaturized Ames test for weak mutagens using the pre-incubation method with strains TA97 and TA97a as alternatives to TA1537. The results of the study confirmed that the miniaturized Ames test showed similar trends in detection sensitivity and dose-response relationship compared to the standard method. Furthermore, we will also show data for WP2uvrA in the minimized Ames tests, and discuss the usefulness, application, and challenges of the minimized methods.

Axcelead’s Solution
Genotoxicity could be a “killer tox” that will result in suspending the development of pharmaceuticals, cosmetics, and functional foods. In genotoxicity evaluations for screening, the test systems are required to have high accuracy and to reduce the quantities of the compound. We would like to share our knowledge and applications to address the needs for genotoxicity screening. Please take this opportunity to consult with us regarding genotoxicity studies. We offer a comprehensive range of solutions for genotoxicity studies, including in silico, in vitro, and in vivo studies, as well as follow-up studies.